Prospective cohort of cryobiopsy in interstitial lung diseases: a single center experience

Author:

Ribeiro Neto Manuel L.,Arrossi Andrea Valeria,Yadav Ruchi,Culver Daniel A.,Mukhopadhyay Sanjay,Parambil Joseph G.,Southern Brian D.,Tolle Leslie,Pande Aman,Almeida Francisco A.,Sahoo Debasis,Glennie Jessica,Ahmad Usman,Mehta Atul C.,Gildea Thomas R.

Abstract

Abstract Rationale Transbronchial cryobiopsy has been increasingly used to diagnose interstitial lung diseases. However, there is uncertainty regarding its accuracy and risks, mainly due to a paucity of prospective or randomized trials comparing cryobiopsy to surgical biopsy. Objectives To evaluate the diagnostic yield and complications of cryobiopsy in patients selected by multidisciplinary discussion. Methods This was a prospective cohort from 2017 to 2019. We included consecutive patients with suspected interstitial lung diseases being considered for lung biopsy presented at our multidisciplinary meeting. Measurements and main results Of 112 patients, we recommended no biopsy in 31, transbronchial forceps biopsy in 16, cryobiopsy in 54 and surgical biopsy in 11. By the end of the study, 34 patients had had cryobiopsy and 24 patients, surgical biopsy. Overall pathologic and multidisciplinary diagnostic yield of cryobiopsy was 47.1% and 61.8%, respectively. The yield increased over time for both pathologic (year 1: 28.6%, year 2: 54.5%, year 3: 66.7%, p = 0.161) and multidisciplinary (year 1: 50%, year 2: 63.6%, year 3: 77.8%, p = 0.412) diagnosis. Overall rate of grade 4 bleeding after cryobiopsy was 11.8%. Cryobiopsy required less chest tube placement (11.8% vs 100%, p < 0.001) and less hospitalizations compared to surgical biopsy (26.5% vs 95.7%, p < 0.001), but hospitalized patients had a longer median hospital stay (2 days vs 1 day, p = 0.004). Conclusions Diagnostic yield of cryobiopsy increased over time but the overall grade 4 bleeding rate was 11.8%.

Publisher

Springer Science and Business Media LLC

Subject

Pulmonary and Respiratory Medicine

Reference26 articles.

1. Guenther A, Krauss E, Tello S, et al. The European IPF registry (eurIPFreg ): baseline characteristics and survival of patients with idiopathic pulmonary fibrosis. Respir Res. 2018;19(141):1–10.

2. Babiak A, Hetzel J, Krishna G, et al. Transbronchial cryobiopsy : a new tool for lung biopsies. Respiration. 2009;78:203–8.

3. Ravaglia C, Bonifazi M, Wells U, Tomassetti S. Safety and diagnostic yield of transbronchial lung cryobiopsy in diffuse parenchymal lung diseases : a comparative study versus video-assisted thoracoscopic lung biopsy and a systematic review of the literature. Respiratio. 2016;91:215–27.

4. Sharp C, Mccabe M, Adamali H, Medford AR. Use of transbronchial cryobiopsy in the diagnosis of interstitial lung disease—a systematic review and cost analysis. QJM. 2017;110:207–14.

5. Iftikhar I, Alghothani L, Sardi A, Berkowitz D, Musani A. Transbronchial lung cryobiopsy and video-assisted thoracoscopic lung biopsy in the diagnosis of diffuse parenchymal lung disease a meta-analysis of diagnostic test accuracy. Ann Am Thorac Soc. 2017;14(7):1197–211.

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1. Cryobiopsy in Interstitial Lung Disease: Is It Prime Time?;Current Pulmonology Reports;2023-06-01

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