Author:
Peng You-Fan,Lu Fei-Yan,Ma Li-Ya
Abstract
Abstract
Objective
We aimed to assess the association between serum bilirubin levels and interstitial lung disease (ILD) in patients with Primary Sjögren’s syndrome (pSS).
Materials and methods
The retrospectively analysis included 89 consecutive patients with pSS, we collected the clinical materials of pSS patients from the electronic medical records, and all pSS patients were divide into pSS with ILD group and pSS without ILD group.
Results
Serum bilirubin levels were significantly lower in pSS patients with ILD than those without ILD (p = 0.010). Serum bilirubin levels showed a significant negative correlation with erythrocyte sedimentation rate (ESR) (r = -0.321, p = 0.002) in patients with pSS. A multivariable logistic regression analysis confirmed that serum bilirubin presented an independent association with ILD in patients with pSS (OR = 0.841, 95%CI:0.728–0.972, p = 0.019).
Conclusion
Serum bilirubin is independently associated with ILD and therefore may be a promising marker of ILD in patients with pSS.
Publisher
Springer Science and Business Media LLC
Subject
Pulmonary and Respiratory Medicine
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