Author:
Gu Lei,Liu Wei,Ru Meng,Lin Jing,Yu Guoqing,Ye Jia,Zhu Zheng-an,Liu Yuebin,Chen Jian,Lai Guoxiang,Wen Wen
Abstract
Abstract
Background
Chlamydia psittaci pneumonia is a zoonotic infectious disease caused by Chlamydia psittaci. Diagnostic tools, including culture, serologic test and PCR-based methods, are available but prone to false negative results.
Case presentation
This report included five cases of Chlamydia psittaci pneumonia. Symptoms and signs common to all 5 cases included fever, coughing, generalized muscle ache, and most notably, inflammatory infiltration of the lungs upon chest CT and X-ray. Metagenomic next-generation sequencing (mNGS) revealed the presence of Chlamydia psittaci in biopsy lung tissue in 3 cases and bronchoalveolar lavage fluid in the remaining 2 cases. Three patients responded to doxycycline plus moxifloxacin; two patients responded to moxifloxacin alone.
Conclusions
mNGS could be used to diagnose Chlamydia psittaci pneumonia.
Funder
National Key Clinical Specialty Discipline Construction Program of China
Publisher
Springer Science and Business Media LLC
Subject
Pulmonary and Respiratory Medicine
Reference11 articles.
1. de Gier B, Hogerwerf L, Dijkstra F, van der Hoek W. Disease burden of psittacosis in the Netherlands. Epidemiol Infect. 2018;146:303–5.
2. Nieuwenhuizen AA, Dijkstra F, Notermans DW, van der Hoek W. Laboratory methods for case finding in human psittacosis outbreaks: a systematic review. BMC Infect Dis. 2018;18(442):1–16.
3. Hogerwerf L, DE Gier B, Baan B, Van Der Hoek W. Chlamydia psittaci (psittacosis) as a cause of community-acquired pneumonia: a systematic review and meta-analysis. Epidemiol Infect. 2017;145:3096–105.
4. Gu W, Miller S, Chiu CY. Clinical metagenomic next-generation sequencing for pathogen detection. Annu Rev Pathol. 2019;14:319–38.
5. Radomski N, Einenkel R, Muller A, Knittler MR. Chlamydia-host cell interaction not only from a bird's eye view: some lessons from chlamydia psittaci. FEBS Lett. 2016;590:3920–40.
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