Author:
Uranga Ane,Artaraz Amaia,Bilbao Amaia,Quintana Jose María,Arriaga Ignacio,Intxausti Maider,Lobo Jose Luis,García Julia Amaranta,Camino Jesus,España Pedro Pablo
Abstract
Abstract
Background
The optimal duration of antibiotic treatment for community-acquired pneumonia (CAP) is not well established. The aim of this study was to assess the impact of reducing the duration of antibiotic treatment on long-term prognosis in patients hospitalized with CAP.
Methods
This was a multicenter study assessing complications developed during 1 year of patients previously hospitalized with CAP who had been included in a randomized clinical trial concerning the duration of antibiotic treatment. Mortality at 90 days, at 180 days and at 1 year was analyzed, as well as new admissions and cardiovascular complications. A subanalysis was carried out in one of the hospitals by measuring C-reactive protein (CRP), procalcitonin (PCT) and proadrenomedullin (proADM) at admission, at day 5 and at day 30.
Results
A total of 312 patients were included, 150 in the control group and 162 in the intervention group. Ninety day, 180 day and 1-year mortality in the per-protocol analysis were 8 (2.57%), 10 (3.22%) and 14 (4.50%), respectively. There were no significant differences between both groups in terms of 1-year mortality (p = 0.94), new admissions (p = 0.84) or cardiovascular events (p = 0.33). No differences were observed between biomarker level differences from day 5 to day 30 (CRP p = 0.29; PCT p = 0.44; proADM p = 0.52).
Conclusions
Reducing antibiotic treatment in hospitalized patients with CAP based on clinical stability criteria is safe, without leading to a greater number of long-term complications.
Funder
Sociedad Española de Neumología y Cirugía Torácica
BBK-BIOCRUCES POST-MIR COURSE
HEALTH DEPARTMENT OF BASQUE COUNTRY GOVERNMENT
PHARMACY DEPARTMENT OF SPANISH GOVERNMENT
FELLOWS SCHOLARSHIP SPANISH PULMONOLOGY AND THORACIC SURGERY SOCIETY
Publisher
Springer Science and Business Media LLC
Subject
Pulmonary and Respiratory Medicine
Cited by
3 articles.
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