Author:
Masuda Toshihiro,Nakatani Eiji,Shirai Toshihiro,Akamatsu Taisuke,Tamura Kanami,Takahashi Shingo,Tanaka Yuko,Watanabe Hirofumi,Endo Yoshinari,Suzuki Takahito,Saigusa Mika,Yamamoto Akito,Morita Satoru,Sato Yoko,Asada Kazuhiro
Abstract
Abstract
Background
The effectiveness of the 23-valent pneumococcal polysaccharide vaccine (PPSV23) in preventing pneumococcal pneumonia has been controversial.
Methods
To evaluate the effectiveness of the PPSV23 in elderly outpatients with chronic respiratory diseases, we carried out a case–control study, including 4128 outpatients aged ≥ 65 years, in the respiratory department.
Results
There were 320 vaccinated patients, of which 164 were diagnosed with pneumococcal pneumonia. The adjusted odds ratio was 0.39 (95% confidence interval (CI), 0.17 to 0.89). In the subsets consisting of age groups ≥ 70 and ≥ 75 years, the adjusted odds ratio (95% CI) was respectively 0.16 (0.04 to 0.67) and 0.15 (0.02 to 1.12).
Conclusion
This real-world study suggests that PPSV23 can be useful in preventing pneumococcal pneumonia in the elderly with chronic respiratory diseases.
Publisher
Springer Science and Business Media LLC
Subject
Pulmonary and Respiratory Medicine
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