Author:
Harit Renuka,De Sajal,Singh Piyoosh Kumar,Kashyap Deepika,Kumar Manish,Sahu Dibakar,Yadav Chander Prakash,Mohan Mradul,Singh Vineeta,Tomar Ram Singh,Pandey Kailash C.,Vashisht Kapil
Abstract
AbstractThe present study investigated two single nucleotide polymorphisms (SNPs)—rs479200 and rs516651 in the host EGLN1/PHD2 gene for their association with COVID-19 severity. A retrospective cohort of 158 COVID-19 patients from the Indian population (March 2020 to June 2021) was enrolled. Notably, the frequency of C allele (0.664) was twofold higher than T allele (0.336) in severe COVID-19 patients. Here, we report a novel finding that the C allele of rs479200 in the EGLN1 gene imparts a high risk of severe COVID-19 (odds ratio—6.214 (1.84–20.99) p = 0.003; 9.421 (2.019–43.957) p = 0.004), in additive inheritance model (adjusted and unadjusted, respectively).
Funder
ICMR-National Institute of Malaria Research, Delhi, India
National Research Foundation of Korea
Publisher
Springer Science and Business Media LLC
Cited by
2 articles.
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