Author:
Raissouni Nouhad,Kolesnikov Andrey,Purushothaman Radhika,Sinha Sunil,Bhandari Sonal,Bhangoo Amrit,Malik Shahid,Mathew Revi,Baillargeon Jean-Patrice,Hernandez Maria Isabel,Rosenbaum Michael,Ten Svetlana,Geller David
Abstract
Abstract
Background
First-degree relatives (FDRs) of women with PCOS are at increased risk for impaired insulin sensitivity and diabetes mellitus. Glucose tolerant FDR have evidence of insulin resistance and hyperinsulinemia prior to emergence of frank PCOS.
Aim
To study insulin dynamics parameters in the early adolescent FDR of women with PCOS.
Methods
This is a cross-sectional study involving 18 adolescents whose mothers or sisters had been diagnosed with PCOS and 21 healthy, age-matched control adolescents without FDR. Subjects underwent anthropometric measurements, steroid profiling and frequently sampled Intravenous Glucose Tolerance Test (IVGTT), Homeostasis Model Assessment (HOMA) index, Glucose Disposal Index (GDI), Acute Insulin Response (AIR) and Quantitative insulin sensitivity check index (QUICKI) were derived from IVGTT results.
Results
FDRs showed significantly higher mean HOMA and lower GDI. There were no differences in mean age or BMI Z-score between the cohorts. No differences in sex steroids or AIR were identified between groups.
Conclusion
Female adolescent FDR of women with PCOS have higher HOMA index and lower QUICKI, reflecting altered insulin sensitivity and lower GDI reflecting poorer beta-cell function. The presence of multiple risk factors for type 2 diabetes suggests that aggressive screening of the early adolescent FDR of women with PCOS is indicated.
Publisher
Springer Science and Business Media LLC
Cited by
12 articles.
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