Author:
El Chediak Alissar,Janom Khaled,Koubar Sahar H.
Abstract
AbstractKidney injury is a common finding in patients with liver disease. Bile cast nephropathy (also known as cholemic nephropathy) is an overlooked cause of renal injury in patients with hyperbilirubinemia. It can occur as a result of the toxic effects of bilirubin and bile acids on the renal tubules via several mechanisms. Bile cast nephropathy has characteristic histopathological changes consisting of bilirubin cast deposition in the distal nephron along with tubular epithelial cell injury. Treatment is based on the reversal of liver injury. This review aims to describe bile cast nephropathy in terms of its clinical and morphological features and to shed light on diagnostic techniques. In addition, we present data on management of such nephropathy while reviewing all the reported cases of bile cast nephropathy.
Publisher
Springer Science and Business Media LLC
Subject
Transplantation,Urology,Nephrology
Reference55 articles.
1. Krones E, Wagner M, Eller K, et al. Bile acid-induced cholemic nephropathy. Dig Dis. 2015;33:367–75.
2. Patel J, Walayat S, Kalva N, et al. Bile cast nephropathy: a case report and review of the literature. World J Gastroenterol. 2016;22:6328–34.
3. van Slambrouck CM, Salem F, Meehan SM, et al. Bile cast nephropathy is a common pathologic finding for kidney injury associated with severe liver dysfunction. Kidney Int. 2013;84:192–7.
4. Alnasrallah B, Collins JF, Zwi LJ. Bile nephropathy in flucloxacillin-induced cholestatic liver dysfunction. Case Rep Nephrol. 2016;2016:4162674.
5. Romano TG, Vieira Junior JM. Do biliary salts have role on acute kidney injury development? J Clin Med Res. 2015;7:667–71.
Cited by
17 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献