Abstract
Abstract
Background
QT dispersion (QTD) represents inhomogeneous ventricular repolarization such that an increased QTD may predispose the heart to malignant ventricular arrhythmias (VAs). This study was conducted to compare QTD in patients with ST-elevation myocardial infarction (STEMI) before and after treatment by streptokinase (SK) versus primary percutaneous coronary intervention (PCI).
Methods
The present case–control study was conducted on 185 STEMI patients who received SK (115 cases) or underwent primary PCI (70 cases). QTD and QT corrected dispersion before and 24 h after treatment. Likewise, they were also found to correct fatal arrhythmias (VT and VF) during the first 24 h after admission, and ejection fraction (EF) 24 h after treatment was evaluated.
Results
QTD decreased in the primary PCI group, though no significant difference was seen between the two studied groups (P > 0.05). A significant increase was detected in the EF mean values for the primary PCI-treated patients (P = 0.022). Moreover, there was a significant reduction in QTD of patients with fatal arrhythmias in the primary PCI group (P = 0.022).
Conclusion
An overall QTD reduction in the primary PCI group and a significant decrease in QTD of patients with fatal arrhythmias in the primary PCI group show that this treatment strategy is more efficient than thrombolytic therapy. As an important indicator of proper myocardial function, EF can independently predict improved myocardial function in the primary PCI group.
Publisher
Springer Science and Business Media LLC
Subject
Cardiology and Cardiovascular Medicine
Reference23 articles.
1. Vesterinen P. Electrocardiographic repolarization variables in detecting myocardial infarction and ischemic injury: From body surface potential mapping to a single lead. 2007.
2. Akbari H, Asadikaram G, Vakili S, Masoumi M. Atorvastatin and losartan may upregulate renalase activity in hypertension but not coronary artery diseases: the role of gene polymorphism. J Cell Biochem. 2019;120:9159–71.
3. Helal AM, Shaheen SM, Elhammady WA, Ahmed MI, Abdel-Hakim AS, Allam LE. Primary PCI versus pharmacoinvasive strategy for ST elevation myocardial infarction. IJC Hear Vasc. 2018;21:87–93.
4. de Campos Martins EC, de Melo Bernardi FL, Junior OTM, Micari A, Hopkins LN, Cremonesi A, et al. Similarities and differences between primary percutaneous coronary intervention and mechanical thrombectomy. JACC CardiovascInterv. 2020;13:1683–96.
5. Bilen E, Yasar AS, Bilge M, Yuksel IO, Aslantas U, Kurt M, et al. Effect of primary percutaneous coronary intervention on myocardial repolarization. J Cardiovasc Med. 2011;12:795–9.
Cited by
7 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献