Author:
Yang Hao-Ran,Xiong Tian-Yuan,Zhang Yi,He Jing-Jing,Feng Yuan,Chen Mao
Abstract
Abstract
Background
We aim to determine predictors of inadequate left ventricular mass index (LVMi) regression at mid-term after transcatheter aortic valve replacement (TAVR), including the potential role of epicardial adipose tissue (EAT).
Methods
We retrospectively reviewed patients with both echocardiographic assessments and multi-slice computed tomography (MSCT) obtained one year after TAVR. The change of LVMi, the volume and the average CT attenuation of EAT from baseline to one-year follow-up was calculated. Patients were divided into two groups by the percentage change of LVMi at a cut-off of 15%.
Results
A total of 152 patients were included with a median age of 74 years (interquartile range [IQR] 69–78 years) and 56.6% being male. LVMi decreased (P < 0.0001) while EAT volume increased and the average CT attenuation decreased (both P < 0.0001) at one year. Baseline atrial fibrillation (P = 0.042), mitral regurgitation ≥ mild (P = 0.006), aortic regurgitation (AR) > mild (P = 0.001) and the change in the average CT attenuation of EAT (P = 0.026) were different between the decrease of LVMi ≥ 15% and < 15%. AR > mild at baseline was the only statistically significant predictor of a decrease of LVMi < 15% at one year (OR 0.33, 95% CI: 0.13 to 0.84, P = 0.021) in multivariate regression.
Conclusions
Concomitant more-than-mild AR might predict better left ventricular reverse remodeling regression after TAVR.
Funder
National Natural Science Foundation of China
Key Research and Development Project of Science & Technology Department of Sichuan Province
Key Research and Development Support Project of Science & Technology Department of Chengdu
Chinese Medical Association Cardiovascular Branch (CSC) Clinical Research Special Fund Project
West China Hospital “1·3·5” Discipline of Excellence Project
Publisher
Springer Science and Business Media LLC
Subject
Cardiology and Cardiovascular Medicine