Author:
Deng Yingjian,Zhou Faguang,Li Qiang,Guo Jincun,Cai Binni,Li Guiyang,Liu Jianghai,Li Linlin,Zheng Qi,Chang Dong
Abstract
AbstractBackgroundThe importance of inflammation in thrombosis is increasingly appreciated. Neutrophil-lymphocyte ratio (NLR) and monocyte to high-density lipoprotein ratio (MHR) are important indicators of systemic inflammation. This study aimed to investigate the associations between NLR and MHR with left atrial appendage thrombus (LAAT) and spontaneous echo contrast (SEC) in patients with non-valvular atrial fibrillation.MethodsThis retrospective, cross-sectional study enrolled 569 consecutive patients with non-valvular atrial fibrillation. Multivariable logistic regression analysis was used to investigate independent risk factors of LAAT/SEC. Receiver operating characteristic (ROC) curves were used to evaluate the specificity and sensitivity of NLR and MHR in predicting LAAT/SEC. Subgroup and Pearson correlation analyses were used to assess the correlations between NLR and MHR with the CHA2DS2-VASc score.ResultsMultivariate logistic regression analysis showed that NLR (OR: 1.49; 95%CI: 1.173–1.892) and MHR (OR: 2.951; 95%CI: 1.045–8.336) were independent risk factors for LAAT/SEC. The area under the ROC curve of NLR (0.639) and MHR (0.626) was similar to that of the CHADS2score (0.660) and CHA2DS2-VASc score (0.637). Subgroup and Pearson correlation analyses showed significant but very weak associations between NLR (r = 0.139,P < 0.05) and MHR (r = 0.095,P < 0.05) with the CHA2DS2-VASc score.ConclusionGenerally, NLR and MHR are independent risk factors for predicting LAAT/SEC in patients with non-valvular atrial fibrillation.
Funder
the Fujian Provincial Health and Family Planning Youth Scientific Research Project
the Medical and health care guideline project of Xiamen
the Scientific and technological innovation joint capital projects of Fujian Province
Publisher
Springer Science and Business Media LLC
Subject
Cardiology and Cardiovascular Medicine