Abstract
Abstract
Background
Addison’s disease which is due to dysfunction of the adrenal gland, with abnormal secretion of glucocorticoids and mineralocorticoids, is rare. By inducing inflammation and disorders of water and electrolyte metabolism, Addison’s disease may accelerate progression of co-existed cardiovascular diseases. Addison’s disease combined with cardiovascular disease is infrequent, only 10 cases in the literature.
Case presentation
We reported a 51-year-old male patient with unstable angina pectoris and hypotension. Changes on coronary angiography within 2 years suggested rapid progression of coronary artery disease in a patient with low cardiovascular risk. An additional clue of skin hyperpigmentation, fatigue and further examination confirmed the diagnosis of Addison’s disease caused by adrenal tuberculosis. After hormone replacement treatment, the frequency and severity of the angina pectoris were alleviated significantly, as were hypotension, hyperpigmentation and fatigue.
Conclusions
The combination of Addison’s disease and coronary artery disease in one patient is rare. Addison’s disease can induce inflammation and disorders of water and electrolyte metabolism, which may further accelerate the course of coronary artery disease. Meanwhile, the hypotension in Addison’s disease may affect the coronary blood flow, which may result in an increased susceptibility to unstable angina in the presence of coronary stenosis. So, we should analyze comprehensively if the coronary artery disease progress rapidly.
Publisher
Springer Science and Business Media LLC
Subject
Cardiology and Cardiovascular Medicine
Reference25 articles.
1. Thomas A. On the constitutional and local effects of disease of the supra-renal capsules. Br Foreign Med-Chir Rev. 1856;18(36):404–13.
2. Husebye ES, Allolio B, Arlt W, Badenhoop K, Bensing S, Betterle C, Falorni A, Gan EH, Hulting AL, Kasperlik-Zaluska A, et al. Consensus statement on the diagnosis, treatment and follow-up of patients with primary adrenal insufficiency. J Intern Med. 2014;275(2):104–15.
3. Carey RM. The changing clinical spectrum of adrenal insufficiency. Ann Intern Med. 1997;127(12):1103–5.
4. Wang L, Lu L, Lu Z, Chen S, Zhu H, Pan H, Dduan L, Yang H, Wang L, Yuan T, et al. Etiology and clinical features of primary adrenal insufficiency. Natl Med J China. 2020;12(100):915–21.
5. The writing Committee of the Report on Cardiovascular Health and Disease in China: Report on Cardiovascular health and diseases burden in china: an updated summary of 2020. Chin Circ J 2021, 36(06):521–545.
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献