Author:
Klein M.,Polgart E.,Hallermann C.,Schulze H. J.,Hölzle F.,Wermker K.
Abstract
Abstract
Background
Among cutaneous squamous cell carcinomas, the ear (ecSCC) is one of the most common sites. Loco regional lymph node metastasis is found in six to eleven percent of cases, corresponding to increased metastasis compared to other sites. The aim of this study was to test the markers PD-L1, PD-1, CD4, CD8, and FoxP3 for suitability as prognostic predictive markers.
Methods
Sixty-four patients with ecSCC were included in this study. The expression of immunohistochemical markers (PD-L1, PD-1, CD4, CD8, FOXP3) was correlated with retrospective clinic pathological parameters (lymph node metastasis, distant metastasis, lymph node metastasis during follow-up, disease progression, disease-specific death).
Results
There was a correlation between increased disease specific death and a weak Foxp3 (p = 0.003) or reduced CD8 (p = 0.04). A PD-L1 expression > 1% was found in 39.1% of patients.
Conclusion
The investigated markers (CD4, CD8, FoxP3, PD-1, PD-L1) seem overall rather inappropriate for prognostic evaluation in ecSCC. Only the correlation of disease specific death with CD8 or FoxP3 seems to be worth testing in larger collectives.
Publisher
Springer Science and Business Media LLC
Subject
Neurology (clinical),General Dentistry,Otorhinolaryngology
Reference25 articles.
1. Leiter U, Heppt MV, Steeb T, Amaral T, Bauer A, Becker JC. S3 guideline for actinic keratosis and cutaneous squamous cell carcinoma (cSCC) – short version, part 2: epidemiology, surgical and systemic treatment of cSCC, follow-up, prevention and occupational disease. J Dtsch Dermatol Ges. 2020;18(4):400–13.
2. Wermker K, Kluwig J, Schipmann S, Klein M, Schulze HJ, Hallermann C. Prediction score for lymph node metastasis from cutaneous squamous cell carcinoma of the external ear. Eur J Surg Oncol Januar. 2015;41(1):128–35.
3. Wermker K, Belok F, Schipmann S, Klein M, Schulze HJ, Hallermann C. Prediction model for lymph node metastasis and recommendations for elective neck dissection in lip cancer. J Craniomaxillofac Surg Mai. 2015;43(4):545–52.
4. Alam M, Ratner D. Cutaneous squamous-cell carcinoma. N Engl J Med 29 März. 2001;344(13):975–83.
5. Salmaninejad A, Khoramshahi V, Azani A, Soltaninejad E, Aslani S, Zamani MR, u. a. PD-1 and cancer: molecular mechanisms and polymorphisms. Immunogenetics. 22. Juni 2017;