Activation of neutral-sphingomyelinase, MAPKs, and p75 NTR-mediating caffeic acid phenethyl ester–induced apoptosis in C6 glioma cells

Author:

Tseng Tsui-Hwa,Shen Chien-Heng,Huang Wen-Shih,Chen Cheng-Nan,Liang Wen-Hai,Lin Tseng-Hsi,Kuo Hsing-Chun

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Biochemistry (medical),Cell Biology,Clinical Biochemistry,Molecular Biology,General Medicine,Endocrinology, Diabetes and Metabolism

Reference28 articles.

1. Chiao C, Carothers AM, Grunberger D, Solomon G, Preston GA, Barrett JC: Apoptosis and altered redox state induced by caffeic acid phenethyl ester (CAPE) in transformed rat fibroblast cells. Cancer Res. 1995, 55: 3576-3583.

2. Fesen MR, Pommier Y, Leteurtre F, Hiroguchi S, Yung J, Kohn KW: Inhibition of HIV-1 integrase by flavones, caffeic acid phenethyl ester (CAPE) and related compounds. Biochem Pharmacol. 1994, 48: 595-608. 10.1016/0006-2952(94)90291-7.

3. Natarajan K, Singh S, Burke TR, Grunberger D, Aggarwal BB: Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B. Proc Natl Acad Sci U S A. 1996, 93: 9090-9095. 10.1073/pnas.93.17.9090.

4. Michaluart P, Masferrer JL, Carothers AM, Subbaramaiah K, Zweifel BS, Koboldt C, Mestre JR, Grunberger D, Sacks PG, Tanabe T, Dannenberg AJ: Inhibitory effects of caffeic acid phenethyl ester on the activity and expression of cyclooxygenase-2 in human oral epithelial cells and in a rat model of inflammation. Cancer Res. 1999, 59: 2347-2352.

5. Watabe M, Hishikawa K, Takayanagi A, Shimizu N, Nakaki T: Caffeic acid phenethyl ester induces apoptosis by inhibition of NFkappa B and activation of Fas in human breast cancer MCF-7 cells. J Biol Chem. 2004, 279: 6017-6026.

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