Tamoxifen decreases ovarian toxicity without compromising cancer treatment in a rat model of mammary cancer

Author:

Nynca AnnaORCID,Swigonska Sylwia,Ruszkowska Monika,Sadowska Agnieszka,Orlowska Karina,Molcan Tomasz,Myszczynski Kamil,Otrocka-Domagala Iwona,Paździor-Czapula Katarzyna,Kurowicka Beata,Petroff Brian Kelli,Ciereszko Renata Elzbieta

Abstract

Abstract Background Premenopausal women diagnosed with breast cancer often face aggressive chemotherapy resulting in infertility. Tamoxifen (TAM) is a selective estrogen receptor modulator that was previously suggested as a protective agent against chemotherapy-induced ovarian failure. In the current study, we examined mechanisms of the protective action of TAM in the ovaries of tumor-bearing rats treated with the chemotherapy drug cyclophosphamide (CPA). Results TAM prevented CPA-induced loss of ovarian follicular reserves. The protective TAM effect in the rat ovary partially resulted from decreased apoptosis. In addition, transcriptomic and proteomic screening also implicated the importance of DNA repair pathways as well as cell adhesion and extracellular matrix remodeling in the protective ovarian actions of TAM. Conclusions Tamoxifen shielded the ovary from the side effects of chemotherapy without lessening the tumoricidal actions of mammary cancer treatment. Graphical Abstract

Funder

National Science Center

Publisher

Springer Science and Business Media LLC

Subject

Genetics,Biotechnology

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Molecular Action of Tamoxifen in the Ovaries of Rats with Mammary Neoplasia;International Journal of Molecular Sciences;2023-10-30

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