Author:
Han Lei,Lan Tianming,Lu Yaxian,Zhou Mengchao,Li Haimeng,Lu Haorong,Wang Qing,Li Xiuyun,Du Shan,Guan Chunyu,Zhang Yong,Sahu Sunil Kumar,Qian Puyi,Zhang Shaofang,Zhou Hongcheng,Guo Wei,Chai Hongliang,Wang Sibo,Liu Quan,Liu Huan,Hou Zhijun
Abstract
Abstract
Background
The evolution of parasites is often directly affected by the host's environment. Studies on the evolution of the same parasites in different hosts are of great interest and are highly relevant to our understanding of divergence.
Methods
Here we performed whole-genome sequencing of Parascaris univalens from different Equus hosts (horses, zebras and donkeys). Phylogenetic and selection analyses were performed to study the divergence and adaptability of P. univalens.
Results
At the genetic level, multiple lines of evidence indicate that P. univalens is mainly separated into two clades (horse-derived and zebra & donkey-derived). This divergence began 300–1000 years ago, and we found that most of the key enzymes related to glycolysis were under strong positive selection in zebra & donkey-derived roundworms, whereas the lipid-related metabolic system was under positive selection in horse-derived roundworms, indicating that the adaptive evolution of metabolism has occurred over the past few centuries. In addition, we found that some drug-related genes showed a significantly higher degree of selection in diverse populations.
Conclusions
This work reports the adaptive evolution and divergence trend of P. univalens in different hosts for the first time. Its results indicate that the divergence of P. univalens is a continuous, dynamic process. Furthermore, the continuous monitoring of the effects of differences in nutritional and drug histories on the rapid evolution of roundworms is conducive to further understanding host-parasite interactions.
Funder
the National Key R&D Program
Open Project of Key Laboratory of SFGA on Conservation Biology of Rare Animals in The Giant Panda National Park
Fundamental Research Funds for the Central Universities of China
the Fundamental Research Funds for the Central Universities of China
the Foundation of Key Laboratory of State Forestry and Grassland Administration (State Park Administration) on Conservation Biology of Rare Animals in the Giant Panda National Park
the Guangdong Provincial Key Laboratory of Genome Read and Write
the Pearl River Talent Recruitment Program in Guangdong Province
Forestry science and technology research project
Publisher
Springer Science and Business Media LLC
Cited by
3 articles.
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