Author:
Ncube Denver,Tallafuss Alexandra,Serafin Jen,Bruckner Joseph,Farnsworth Dylan R.,Miller Adam C.,Eisen Judith S.,Washbourne Philip
Abstract
Abstract
Background
An essential determinant of a neuron’s functionality is its neurotransmitter phenotype. We previously identified a defined subpopulation of cholinergic neurons required for social orienting behavior in zebrafish.
Results
We transcriptionally profiled these neurons and discovered that they are capable of synthesizing both acetylcholine and GABA. We also established a constellation of transcription factors and neurotransmitter markers that can be used as a “transcriptomic fingerprint” to recognize a homologous neuronal population in another vertebrate.
Conclusion
Our results suggest that this transcriptomic fingerprint and the cholinergic-GABAergic neuronal subtype that it defines are evolutionarily conserved.
Funder
Fulbright Association
NIH Office of the Director
National Institute of Mental Health
Publisher
Springer Science and Business Media LLC
Cited by
6 articles.
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