Author:
López Sastre José B,Pérez Solís David,Roqués Serradilla Vicente,Fernández Colomer Belén,Coto Cotallo Gil D,Krauel Vidal Xavier,Narbona López Eduardo,García del Río Manuel,Sánchez Luna Manuel,Belaustegui Cueto Antonio,Moro Serrano Manuel,Urbón Artero Alfonso,Álvaro Iglesias Emilio,Cotero Lavín Ángel,Martínez Vilalta Eduardo,Jiménez Cobos Bartolomé,
Abstract
Abstract
Background
It has recently been suggested that serum procalcitonin (PCT) is of value in the diagnosis of neonatal sepsis, with varying results. The aim of this prospective multicenter study was to assess the usefulness of PCT as a marker of neonatal sepsis of nosocomial origin.
Methods
One hundred infants aged between 4 and 28 days of life admitted to the Neonatology Services of 13 acute-care teaching hospitals in Spain over 1-year with clinical suspicion of neonatal sepsis of nosocomial origin were included in the study. Serum PCT concentrations were determined by a specific immunoluminometric assay. The reliability of PCT for the diagnosis of nosocomial neonatal sepsis at the time of suspicion of infection and at 12–24 h and 36–48 h after the onset of symptoms was calculated by receiver-operating characteristics (ROC) curves. The Youden's index (sensitivity + specificity - 1) was used for determination of optimal cutoff values of the diagnostic tests in the different postnatal periods. Sensitivity, specificity, and the likelihood ratio of a positive and negative result with the 95% confidence interval (CI) were calculated.
Results
The diagnosis of nosocomial sepsis was confirmed in 61 neonates. Serum PCT concentrations were significantly higher at initial suspicion and at 12–24 h and 36–48 h after the onset of symptoms in neonates with confirmed sepsis than in neonates with clinically suspected but not confirmed sepsis. Optimal PCT thresholds according to ROC curves were 0.59 ng/mL at the time of suspicion of sepsis (sensitivity 81.4%, specificity 80.6%); 1.34 ng/mL within 12–24 h of birth (sensitivity 73.7%, specificity 80.6%), and 0.69 ng/mL within 36–48 h of birth (sensitivity 86.5%, specificity 72.7%).
Conclusion
Serum PCT concentrations showed a moderate diagnostic reliability for the detection of nosocomial neonatal sepsis from the time of suspicion of infection. PCT is not sufficiently reliable to be the sole marker of sepsis, but would be useful as part of a full sepsis evaluation.
Publisher
Springer Science and Business Media LLC
Subject
Pediatrics, Perinatology, and Child Health
Reference28 articles.
1. Peter G, Cashore WJ: Infections acquired in the nursery: epidemiology and control. Infectious diseases of the fetus and newborn infant. Edited by: Remington JS and Klein JO. 2001, Philadelphia, Saunders, 1264-1283. fifth
2. López Sastre JB, Coto Cotallo D, Fernández Colomer B, Grupo de Hospitales Castrillo: Neonatal sepsis of nosocomial origin: an epidemiological study from the "Grupo de Hospitales Castrillo". J Perinat Med. 2002, 30: 149-157. 10.1515/JPM.2002.019.
3. Polin RA: The "ins and outs" of neonatal sepsis. J Pediatr. 2003, 143: 3-4. 10.1016/S0022-3476(03)00271-3.
4. Weinberg GA, Powell KR: Laboratory aids for diagnosis of neonatal sepsis. Infectious diseases of the fetus and newborn infant. Edited by: Remington JS and Klein JO. 2001, Philadelphia, Saunders, 1327-1344. fifth
5. Müller B, White JC, Nylén ES, Snider RH, Becker KL, Habener JF: Ubiquitous expression of the calcitonin-i gene in multiple tissues in response to sepsis. J Clin Endocrinol Metab. 2001, 86: 396-404. 10.1210/jc.86.1.396.
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