Nanosensitizers for sonodynamic therapy for glioblastoma multiforme: current progress and future perspectives

Author:

Guo Qing-Long,Dai Xing-Liang,Yin Meng-Yuan,Cheng Hong-Wei,Qian Hai-Sheng,Wang Hua,Zhu Dao-Ming,Wang Xian-WenORCID

Abstract

AbstractGlioblastoma multiforme (GBM) is the most common primary malignant brain tumor, and it is associated with poor prognosis. Its characteristics of being highly invasive and undergoing heterogeneous genetic mutation, as well as the presence of the blood–brain barrier (BBB), have reduced the efficacy of GBM treatment. The emergence of a novel therapeutic method, namely, sonodynamic therapy (SDT), provides a promising strategy for eradicating tumors via activated sonosensitizers coupled with low-intensity ultrasound. SDT can provide tumor killing effects for deep-seated tumors, such as brain tumors. However, conventional sonosensitizers cannot effectively reach the tumor region and kill additional tumor cells, especially brain tumor cells. Efforts should be made to develop a method to help therapeutic agents pass through the BBB and accumulate in brain tumors. With the development of novel multifunctional nanosensitizers and newly emerging combination strategies, the killing ability and selectivity of SDT have greatly improved and are accompanied with fewer side effects. In this review, we systematically summarize the findings of previous studies on SDT for GBM, with a focus on recent developments and promising directions for future research.

Funder

the National Natural Science Foundation of China

Clinical Medical University and Hospital Joint Construction of Disciplinary Projects 2021

the Basic and Clinical Cooperative Research and Promotion Program of Anhui Medical University

the Open Fund of Key Laboratory of Antiinflammatory and Immune Medicine

Grants for Scientific Research of BSKY from Anhui Medical University

Publisher

Springer Science and Business Media LLC

Subject

General Medicine

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