Abstract
AbstractGlioblastoma multiforme (GBM) is the most common primary malignant brain tumor, and it is associated with poor prognosis. Its characteristics of being highly invasive and undergoing heterogeneous genetic mutation, as well as the presence of the blood–brain barrier (BBB), have reduced the efficacy of GBM treatment. The emergence of a novel therapeutic method, namely, sonodynamic therapy (SDT), provides a promising strategy for eradicating tumors via activated sonosensitizers coupled with low-intensity ultrasound. SDT can provide tumor killing effects for deep-seated tumors, such as brain tumors. However, conventional sonosensitizers cannot effectively reach the tumor region and kill additional tumor cells, especially brain tumor cells. Efforts should be made to develop a method to help therapeutic agents pass through the BBB and accumulate in brain tumors. With the development of novel multifunctional nanosensitizers and newly emerging combination strategies, the killing ability and selectivity of SDT have greatly improved and are accompanied with fewer side effects. In this review, we systematically summarize the findings of previous studies on SDT for GBM, with a focus on recent developments and promising directions for future research.
Funder
the National Natural Science Foundation of China
Clinical Medical University and Hospital Joint Construction of Disciplinary Projects 2021
the Basic and Clinical Cooperative Research and Promotion Program of Anhui Medical University
the Open Fund of Key Laboratory of Antiinflammatory and Immune Medicine
Grants for Scientific Research of BSKY from Anhui Medical University
Publisher
Springer Science and Business Media LLC
Cited by
64 articles.
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