Abstract
AbstractDespite the widespread use of malaria rapid diagnostic test (RDT) in clinical practice, there are a lot of challenges. We conducted a secondary analysis of 129 malaria RDT data from rounds 5–8 of the World Health Organization (WHO) product testing summary and discuss the causes of false-negative (FN) results with a focus on low parasite density, improper RDT storage, operation and interpretation, and plasmodium falciparum with a pfhrp2/3 gene deletion. The results demonstrated that the malaria RDTs currently commercially available might cause FN results in practice.
Funder
Biosafety Special Program
National Key Laboratory of Science and Technology on Micro/Nano Fabrication
Publisher
Springer Science and Business Media LLC
Reference5 articles.
1. World Health Organization (2018). Malaria rapid diagnostic test performance: results of WHO product testing of malaria RDTs: round 8 (2016–2018). https://apps.who.int/iris/handle/10665/276190
2. Kavanaugh MJ, Azzam SE, Rockabrand DM. Malaria rapid diagnostic tests: literary review and recommendation for a quality assurance, quality control algorithm. Diagnostics (Basel). 2021;11(5):768.
3. World Health Organization (2018). Malaria rapid diagnostic test performance: summary results of WHO product testing of malaria RDTs: round 1–8 (2008–2018). https://apps.who.int/iris/handle/10665/276193
4. Plucinski MM, Dimbu PR, Fortes F, Murphy SC, Smith NT, Cruz KR, et al. Malaria parasite density in individuals with different rapid diagnostic test results and concentrations of HRP2 antigen. Am J Trop Med Hyg. 2019;100:1202–3.
5. Seidahmed OM, Mohamedein MM, Elsir AA, Ali FT, el Malik FM, Ahmed ES. End-user errors in applying two malaria rapid diagnostic tests in a remote area of Sudan. Trop Med Int Health. 2008;13:406–9.