Author:
Chiew Yeong Shiong,Chase J Geoffrey,Shaw Geoffrey M,Sundaresan Ashwath,Desaive Thomas
Abstract
Abstract
Background
Acute Respiratory Distress Syndrome (ARDS) patients require mechanical ventilation (MV) for breathing support. Patient-specific PEEP is encouraged for treating different patients but there is no well established method in optimal PEEP selection.
Methods
A study of 10 patients diagnosed with ALI/ARDS whom underwent recruitment manoeuvre is carried out. Airway pressure and flow data are used to identify patient-specific constant lung elastance (E
lung
) and time-variant dynamic lung elastance (E
drs
) at each PEEP level (increments of 5cmH
2
O), for a single compartment linear lung model using integral-based methods. Optimal PEEP is estimated using E
lung
versus PEEP, E
drs
-Pressure curve and E
drs
Area at minimum elastance (maximum compliance) and the inflection of the curves (diminishing return). Results are compared to clinically selected PEEP values. The trials and use of the data were approved by the New Zealand South Island Regional Ethics Committee.
Results
Median absolute percentage fitting error to the data when estimating time-variant E
drs
is 0.9% (IQR = 0.5-2.4) and 5.6% [IQR: 1.8-11.3] when estimating constant E
lung
. Both E
lung
and E
drs
decrease with PEEP to a minimum, before rising, and indicating potential over-inflation. Median E
drs
over all patients across all PEEP values was 32.2 cmH
2
O/l [IQR: 26.1-46.6], reflecting the heterogeneity of ALI/ARDS patients, and their response to PEEP, that complicates standard approaches to PEEP selection. All E
drs
-Pressure curves have a clear inflection point before minimum E
drs
, making PEEP selection straightforward. Model-based selected PEEP using the proposed metrics were higher than clinically selected values in 7/10 cases.
Conclusion
Continuous monitoring of the patient-specific E
lung
and E
drs
and minimally invasive PEEP titration provide a unique, patient-specific and physiologically relevant metric to optimize PEEP selection with minimal disruption of MV therapy.
Publisher
Springer Science and Business Media LLC
Subject
Radiology, Nuclear Medicine and imaging,Biomedical Engineering,General Medicine,Biomaterials,Radiological and Ultrasound Technology
Cited by
113 articles.
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