Author:
Yammine S. G.,Huybrechts I.,Biessy C.,Dossus L.,Panico S.,Sánchez M. J.,Benetou V.,Turzanski-Fortner R.,Katzke V.,Idahl A.,Skeie G.,Olsen K. Standahl,Tjønneland A.,Halkjaer J.,Colorado-Yohar S.,Heath A. K.,Sonestedt E.,Sartor H.,Schulze M. B.,Palli D.,Crous-Bou M.,Dorronsoro A.,Overvad K.,Gurrea A. Barricarte,Severi G.,Vermeulen R. C.H.,Sandanger T. M.,Travis R. C.,Key T.,Amiano P.,Van Guelpen B.,Johansson M.,Sund M.,Tumino R.,Wareham N.,Sacerdote C.,Krogh V.,Brennan P.,Riboli E.,Weiderpass E.,Gunter M. J.,Chajès V.
Abstract
Abstract
Background
Diet may impact important risk factors for endometrial cancer such as obesity and inflammation. However, evidence on the role of specific dietary factors is limited. We investigated associations between dietary fatty acids and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC).
Methods
This analysis includes 1,886 incident endometrial cancer cases and 297,432 non-cases. All participants were followed up for a mean of 8.8 years. Multivariable Cox proportional hazard models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI) of endometrial cancer across quintiles of individual fatty acids estimated from various food sources quantified through food frequency questionnaires in the entire EPIC cohort. The false discovery rate (q-values) was computed to control for multiple comparisons.
Results
Consumption of n-6 γ-linolenic acid was inversely associated with endometrial cancer risk (HR comparing 5th with 1st quintileQ5−Q1=0.77, 95% CI = 0.64; 0.92, ptrend=0.01, q-value = 0.15). This association was mainly driven by γ-linolenic acid derived from plant sources (HRper unit increment=0.94, 95%CI= (0.90;0.98), p = 0.01) but not from animal sources (HRper unit increment= 1.00, 95%CI = (0.92; 1.07), p = 0.92). In addition, an inverse association was found between consumption of n-3 α-linolenic acid from vegetable sources and endometrial cancer risk (HRper unit increment= 0.93, 95%CI = (0.87; 0.99), p = 0.04). No significant association was found between any other fatty acids (individual or grouped) and endometrial cancer risk.
Conclusion
Our results suggest that higher consumption of γ-linolenic acid and α-linoleic acid from plant sources may be associated with lower risk of endometrial cancer.
Funder
Institut National Du Cancer
ARC
Centre International de Recherche sur le Cancer
Publisher
Springer Science and Business Media LLC
Subject
Cancer Research,Genetics,Oncology
Reference44 articles.
1. Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021 May;71(3):209–249. https://doi.org/10.3322/caac.21660. Epub 2021 Feb 4. PMID: 33538338.
2. Forouzanfar MH, Afshin A, Alexander LT, Anderson RH, Bhutta ZA, Biryukov S, et al. Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990–2015: a systematic analysis for the global burden of Disease Study 2015. The Lancet. 2016;388:10053.
3. Moore K, Brewer MA. Endometrial Cancer: is this a New Disease? Am Soc Clin Oncol Educ Book. 2017;37:435–42.
4. World Cancer Research Fund / American Institute for Cancer Research. Diet, Nutrition, Physical activity and Endometrial cancer, revised 2018.
5. Bruning PF, Bonfrer JM. Free fatty acid concentrations correlated with the available fraction of estradiol in human plasma. Cancer Res. 1986;46(5):2606–9.