Author:
Qi Yuchen,Zhang Yujing,Li Jianwen,Cai Mengting,Zhang Bo,Yu Zhangtao,Li Yuhang,Huang Junkai,Chen Xu,Song Yinghui,Liu Sulai
Abstract
Abstract
Background
Hepatocellular carcinoma (HCC) is one of the most common human cancers with poor prognosis in the world. HCC has become the second leading cause of cancer-related death in China. It is urgent to identify novel biomarker and valid target to effectively diagnose, treat or predict the prognosis of HCC. It has been reported that S100A family is closely related to cell proliferation and migration of different cancers. However, the values of S100As in HCC remain to be further analyzed.
Methods
We investigated the transcriptional and translational expression of S100As, as well as the value of this family in HCC patients from the various databases.
Results
S100A10 was most relevant to HCC.
Conclusions
The results from HCC patients’ tissues and different cells also confirmed the role of S100A10 in HCC. Furthermore, we proved that S100A10 could influenced the cell proliferation of HCC cells via ANXA2/Akt/mTOR pathway. However, it would appear that the relationship between S100A10 and HCC is complex and requires more research.
Funder
National Natural Science Foundation of China
Hunan Provincial Natural Science Foundation of China
Project of Hunan Provincial Health Commission
Innovative program of Hunan Normal University School of Medicine
China Postdoctoral Science Foundation
Youth Talent of Hunan
Natural Science Fund for Excellent Young Scholars of Hunan Province
Chen Xiao-Ping Foundation for Development of Science and Technology of Hubei Province
The Project of Improving the Diagnosis and Treatment Capacity of Hepatobiliary, Pancreas and Intestine in Hunan Province
Publisher
Springer Science and Business Media LLC
Subject
Cancer Research,Genetics,Oncology
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献