Safety and efficacy of lobaplatin combined with 5-fluorouracil as first-line induction chemotherapy followed by lobaplatin-radiotherapy in locally advanced nasopharyngeal carcinoma: preliminary results of a prospective phase II trial

Author:

Ke Liang-Ru,Xia Wei-Xiong,Qiu Wen-Ze,Huang Xin-Jun,Yang Jing,Yu Ya-Hui,Liang Hu,Liu Guo-Ying,Ye Yan-Fang,Xiang Yan-Qun,Guo Xiang,Lv Xing

Funder

the National Nature Science Foundation of China

International Cooperation Project of Science and Technology Plan of Guangdong Province

Science and Technology Plan Project of Guangdong Province

Foundation of Science and Technology Bureau of Guangzhou City

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Genetics,Oncology

Reference33 articles.

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2. Lee N, Harris J, Garden AS, Straube W, Glisson B, Xia P, Bosch W, Morrison WH, Quivey J, Thorstad W, Jones C, Ang KK. Intensity-modulated radiation therapy with or without chemotherapy for nasopharyngeal carcinoma: radiation therapy oncology group phase II trial 0225. J Clin Oncol. 2009;27:3684–90.

3. Al-Sarraf M, LeBlanc M, Giri PG, Fu KK, Cooper J, Vuong T, Forastiere AA, Adams G, Sakr WA, Schuller DE, Ensley JF. Chemoradiotherapy versus radiotherapy in patients with advanced nasopharyngeal cancer: phase III randomized Intergroup study 0099. J CLIN ONCOL. 1998;16:1310–17.

4. Lee AW, Ngan RK, Tung SY, Cheng A, Kwong DL, Lu TX, Chan AT, Chan LL, Yiu H, Ng WT, Wong F, Yuen KT, Yau S, Cheung FY, Chan OS, Choi H, Chappell R. Preliminary results of trial NPC-0501 evaluating the therapeutic gain by changing from concurrent-adjuvant to induction-concurrent chemoradiotherapy, changing from fluorouracil to capecitabine, and changing from conventional to accelerated radiotherapy fractionation in patients with locoregionally advanced nasopharyngeal carcinoma. Cancer Am Cancer Soc. 2015;121:1328–38.

5. Kong L, Hu C, Niu X, Zhang Y, Guo Y, Tham IW, Lu JJ. Neoadjuvant chemotherapy followed by concurrent chemoradiation for locoregionally advanced nasopharyngeal carcinoma: interim results from 2 prospective phase 2 clinical trials. CANCER-AM CANCER SOC. 2013;119:4111–18.

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