Author:
Yu Zhuoya,Ding Mengfei,Cai Yiqing,Lu Tiange,Chen Xiaomin,Zhou Xiangxiang,Wang Xin
Abstract
Abstract
Background
Recent studies have indicated that epigenetic alterations contribute significantly to lymphoma pathogenesis. A type of epigenetic regulation known as histone acetylation plays a crucial role in transcriptional regulation in eukaryotic cells. Specifically, a significant effect of histone acetylation modifications on the abnormal progression and microenvironment of diffuse large B-cell lymphoma (DLBCL) has been observed.
Methods
To provide insight into the significance of histone acetylation-related genes, we developed a HAscore model for analyzing histone acetylation patterns in DLBCL samples. Furthermore, KAT2A, a regulator of histone acetylation, was knocked down in DLBCL cell lines to investigate its role in proliferation, cell cycle, and apoptosis.
Results
The HAscore model has been demonstrated to provide insight into the significance of these patterns, showing that patients with a low HAscore have distinct tumor immune microenvironments and poorer prognoses. Besides, KAT2A was identified as a potential biomarker related to immune infiltration and malignant pathways in DLBCL.
Conclusion
According to these findings, it is evident that the histone acetylation pattern score model is helpful in describing the immune status of DLBCL and that KAT2A may be used as a biomarker for its treatment.
Funder
National Natural Science Foundation of China
China Postdoctoral Science Foundation
Translational Research Grant of NCRCH
Natural Science Foundation of Shandong Province
Key Technology Research and Development Program of Shandong
Taishan Scholars Program of Shandong Province; Shandong Provincial Engineering Research Center of Lymphoma; Academic Promotion Programme of Shandong First Medical University
Publisher
Springer Science and Business Media LLC
Subject
Cancer Research,Genetics,Oncology