An oncogenic mutant of RHEB, RHEB Y35N, exhibits an altered interaction with BRAF resulting in cancer transformation

Author:

Heard Jeffrey J.,Phung Ivy,Potes Mark I.,Tamanoi FuyuhikoORCID

Funder

National Institutes of Health

National Institute of General Medical Sciences

University of California, Los Angeles

JSPS KAKENHI

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Genetics,Oncology

Reference40 articles.

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2. Yamagata K, Sanders LK, Kaufmannn WE, Yee W, Barnes CA, Nathans D, Paul WF. Rheb, a growth factor- and synaptic activity-regulated gene, encodes a novel Ras-related protein. J Biol Chem. 1994;269(23):16333–9.

3. Gromov PS, Madsen P, Tomerup N, Celis JE. A novel approach for expression cloning of small GTPases: identification, tissue distribution and chromosome mapping of the human homolog of rheb. FEBS Lett. 1995;377(2):221–6.

4. Clark JC, Kinch MS, Rogers-Graham K, Sebti SM, Hamilton AD, Der CJ. The Ras-related protein Rheb is Farnesylated and antagonizes Ras signaling and transformation. J Biol Chem. 1997;272(16):10608–15.

5. N. Mizuki, M. Kimura, S. Ohno, S. Miyata, M. Sato, H. Ando, M. Ishihara, K. Goto, S. Watanabe, M. Yamazaki, A. Ono, S. Taguchi, K. Okumura, M. Nogami, H. Taguchi, A. Ando, and H. Inoko, “Isolation of cDNA and genomic clones of a human Ras-related GTP-binding protein gene and its chromosomal localization to the long arm of chromosome 7, 7q36,” 1996.

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