Author:
Guittet Lydia,Quipourt Valérie,Aparicio Thomas,Carola Elisabeth,Seitz Jean-François,Paillaud Elena,Lievre Astrid,Boulahssass Rabia,Vitellius Carole,Bengrine Leila,Canoui-Poitrine Florence,Manfredi Sylvain
Abstract
Abstract
Background
We have done a systematic literature review about CRC Screening over 75 years old in order to update knowledge and make recommendations.
Methods
PUBMED database was searched in October 2021 for articles published on CRC screening in the elderly, and generated 249 articles. Further searches were made to find articles on the acceptability, efficacy, and harms of screening in this population, together with the state of international guidelines.
Results
Most benefit-risk data on CRC screening in the over 75 s derived from simulation studies. Most guidelines recommend stopping cancer screening at the age of 75. In private health systems, extension of screening up to 80–85 years is, based on the life expectancy and the history of screening. Screening remains effective in populations without comorbidity given their better life-expectancy. Serious adverse events of colonoscopy increase with age and can outweigh the benefit of screening. The great majority of reviews concluded that screening between 75 and 85 years must be decided case by case.
Conclusion
The current literature does not allow Evidence-Based Medicine propositions for mass screening above 75 years old. As some subjects over 75 years may benefit from CRC screening, we discussed ways to introduce CRC screening in France in the 75–80 age group.
IRB
An institutional review board composed of members of the 2 learned societies (SOFOG and FFCD) defined the issues of interest, followed the evolution of the work and reviewed and validated the report.
Publisher
Springer Science and Business Media LLC
Subject
Cancer Research,Genetics,Oncology
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