The natural alkaloid Jerantinine B has activity in acute myeloid leukemia cells through a mechanism involving c-Jun
Author:
Funder
Nottinghamshire Leukaemia Appeal
Saudi Arabia Ministry of Education
Publisher
Springer Science and Business Media LLC
Subject
Cancer Research,Genetics,Oncology
Link
http://link.springer.com/content/pdf/10.1186/s12885-020-07119-2.pdf
Reference27 articles.
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2. Newman DJ, Cragg GM. Natural products as sources of new drugs over the 30 years from 1981 to 2010. J Nat Prod. 2012;75(3):311–35.
3. Lim KH, Hiraku O, Komiyama K, Kam TS. Jerantinines A-G, cytotoxic Aspidosperma alkaloids from Tabernaemontana corymbosa. J Nat Prod. 2008;71(9):1591–4.
4. Raja VJ, Lim KH, Leong CO, Kam TS, Bradshaw TD. Novel antitumour indole alkaloid, Jerantinine a, evokes potent G2/M cell cycle arrest targeting microtubules. Investig New Drugs. 2014;32(5):838–50.
5. Qazzaz ME, Raja VJ, Lim KH, Kam TS, Lee JB, Gershkovich P, Bradshaw TD. In vitro anticancer properties and biological evaluation of novel natural alkaloid jerantinine B. Cancer Lett. 2016;370(2):185–97.
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