Author:
Patrikidou Anna,Chaigneau Loic,Isambert Nicolas,Kitikidou Kyriaki,Shanley Ryan,Ray-Coquard Isabelle,Valentin Thibaud,Malivoir Bettina,Laigre Maryline,Bay Jacques-Olivier,Moureau-Zabotto Laurence,Bompas Emmanuelle,Piperno-Neumann Sophie,Penel Nicolas,Alcindor Thierry,Guillemet Cécile,Duffaud Florence,Hügli Anne,Le Pechoux Cécile,Dhermain Frédéric,Blay Jean-Yves,Sperduto Paul W.,Le Cesne Axel
Abstract
Abstract
Background
Brain metastases from sarcomatous lesions pose a management challenge owing to their rarity and the histopathological heterogeneity. Prognostic indices such as the Graded Prognostic Assessment (GPA) index have been developed for several primary tumour types presenting with brain metastases (e.g. lung, breast, melanoma), tailored to the specifics of different primary histologies and molecular profiles. Thus far, a prognostic index to direct treatment decisions is lacking for adult sarcoma patients with brain metastases.
Methods
We performed a multicentre analysis of a national group of expert sarcoma tertiary centres (French Sarcoma Group, GSF-GETO) with the participation of one Canadian and one Swiss centre. The study cohort included adult patients with a diagnosis of a bone or soft tissue sarcoma presenting parenchymal or meningeal brain metastases, managed between January 1992 and March 2012. We assessed the validity of the original GPA index in this patient population and developed a disease-specific Sarcoma-GPA index.
Results
The original GPA index is not prognostic for sarcoma brain metastasis patients. We have developed a dedicated Sarcoma-GPA index that identifies a sub-group of patients with particularly favourable prognosis based on histology, number of brain lesions and performance status.
Conclusions
The Sarcoma-GPA index provides a novel tool for sarcoma oncologists to guide clinical decision-making and outcomes research.
Publisher
Springer Science and Business Media LLC
Subject
Cancer Research,Genetics,Oncology
Cited by
12 articles.
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