Valuable insights from the epacadostat plus pembrolizumab clinical trials in solid cancers
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Publisher
Springer Science and Business Media LLC
Link
https://link.springer.com/content/pdf/10.1186/s12885-024-12432-1.pdf
Reference11 articles.
1. Beatty GL, O’Dwyer PJ, Clark J, et al. First-in-human phase I study of the oral inhibitor of indoleamine 2,3-Dioxygenase-1 Epacadostat (INCB024360) in patients with advanced solid malignancies. Clin Cancer Res. 2017;23:3269–76.
2. Mitchell TC, Hamid O, Smith DC, et al. Epacadostat Plus Pembrolizumab in patients with advanced solid tumors: Phase I results from a multicenter, open-label phase I/II trial (ECHO-202/KEYNOTE-037). J Clin Oncol. 2018;36:3223–30.
3. Powderly JD, Klempner SJ, Naing A, et al. Epacadostat plus pembrolizumab and chemotherapy for advanced solid tumors: results from the phase I/II ECHO-207/KEYNOTE-723 study. Oncologist. 2022;27:905–e848.
4. Perez RP, Riese MJ, Lewis KD et al. Epacadostat plus Nivolumab in patients with advanced solid tumors: preliminary phase I/II results of ECHO-204. J Clin Oncol. 2017;35 Suppl: Abstract 3003.
5. Long GV, Dummer R, Hamid O, et al. Epacadostat plus Pembrolizumab versus placebo plus pembrolizumab in patients with unresectable or metastatic melanoma (ECHO-301/KEYNOTE-252): a phase 3, randomised, double-blind study. Lancet Oncol. 2019;20:1083–97.
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