CD4 and FOXP3 as predictive markers for the recurrence of T3/T4a stage II colorectal cancer: applying a novel discrete Bayes decision rule

Author:

Nakagami Yuki,Hazama Shoichi,Suzuki Nobuaki,Yoshida Shin,Tomochika Shinobu,Matsui Hiroto,Shindo Yoshitaro,Tokumitsu Yukio,Matsukuma Satoshi,Watanabe Yusaku,Iida Michihisa,Tsunedomi Ryouichi,Takeda Shigeru,Fujita Tomonobu,Kawakami Yutaka,Ogihara Hiroyuki,Hamamoto Yoshihiko,Ioka Tatsuya,Tanabe Tsuyoshi,Ueno Tomio,Nagano Hiroaki

Abstract

Abstract Background We recently reported the relapse-free survival (RFS) significance of the combination of CD4+ and forkhead box P3+ (FOXP3) T-cell densities identified by immunohistochemistry in patients with stage I, II, and III colorectal cancer (CRC) who underwent curative resections. This study was designed to determine the optimal combination of markers that predict recurrence in patients with T factors of T3/T4a stage II CRC by applying a novel Bayes decision rule. Methods Using 137 cancer tissue specimens from T3/T4a stage II patients, 12 clinicopathologic and immune factors were analysed as predictive candidates for recurrence. Results Our study showed that the combination of low CD4+ and low FOXP3+ T-cell densities resulted in extremely poor RFS. Conclusions Adjuvant chemotherapy may be considered for patients with a combination of low CD4+ and low FOXP3+ T-cell densities. The discovery of this new prognostic indicator is important for the appropriate management of patients undergoing curative resection for T3/T4a stage II CRC.

Funder

YAMAGUCHI UNIVERSITY FUND

Project for Development of Innovative Research on Cancer Therapeutics

Japan Agency for Medical Research and Development

Leading Advanced Projects for Medical Innovation

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Genetics,Oncology

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