Abstract
Abstract
Background
Evidence linking risk of lymphoma and B-cell lymphoma subtypes to ionizing radiation is inconclusive, particularly at low exposure levels.
Methods
We investigated risk of lymphoma (all subtypes), B-cell lymphomas, and its major subtypes, associated with low-level occupational exposure to ionizing radiation, in 2346 lymphoma cases and 2463 controls, who participated in the multicenter EpiLymph case-control study. We developed a job-exposure matrix to estimate exposure to ionizing radiation, distinguishing between internal and external radiation, and we applied it to the lifetime occupational history of study subjects, We calculated the Odds Ratio (OR) and its 95% confidence interval (95% CI) for lymphoma (all subtypes combined), B-cell lymphoma, and its major subtypes using unconditional, polytomous logistic regression adjusting for age, gender, and education.
Results
We did not observe an association between exposure metrics of external and internal radiation and risk of lymphoma (all subtypes), nor with B-cell lymphoma, or its major subtypes, at the levels regularly experienced in occupational settings. An elevated risk of diffuse large B cell lymphoma was observed among the most likely exposed study subjects with relatively higher exposure intensity, which would be worth further investigation.
Conclusions
Further investigation is warranted on risk of B cell lymphoma subtypes associated with low-level occupational exposure to external ionizing radiation, and to clarify whether lymphoma should be included among the cancer outcomes related to ionizing radiation.
Funder
EC 5th Framework Programme
EC Sixth Framework Program
the Spanish Ministry of Health
Catalan Government
the German Federal Office for Radiation Protection
Ministero dell’Istruzione, dell’Università e della Ricerca
Associazione Italiana per la Ricerca sul Cancro
Publisher
Springer Science and Business Media LLC
Subject
Health, Toxicology and Mutagenesis,Public Health, Environmental and Occupational Health
Reference43 articles.
1. United Nations Scientific Committee on the Effects of Atomic Radiation. Sources, effects, and risks of ionizing radiation. UNSCEAR 2017 Report to the General Assembly. Annex A: Exposures of the Public and Workers from Various Sources of Radiation. Annex B. New York: United Nations; 2018. Available from: http://www.unscear.org/docs/publications/ 2017/ UNSCEAR_2017_Report.pdf. Accessed 16 Jan 2018.
2. Leuraud K, Richardson DB, Cardis E, Daniels RD, Gillies M, O’Hagan JA, et al. Ionising radiation and risk of death from leukaemia and lymphoma in radiation-monitored workers (INWORKS): an international cohort study. Lancet Haematol. 2015;2:e276–81.
3. Richardson DB, Sugiyama H, Wing S, Sakata R, Grant E, Shimizu Y, et al. Positive associations between ionizing radiation and lymphoma mortality among men. Am J Epidemiol. 2009;169:969–76.
4. United Nations Scientific Committee on the Effects of Atomic Radiation. UNSCEAR 2000. Report to the General Assembly, with scientific annexes. Vol.1: Sources. New York: United Nations; 2000. Available from: http://www.unscear.org/docs/publications/2000/ UNSCEAR_ Report_Vol.I.pdf. Accessed 16 Jan 2018.
5. Cardis E, Gilbert ES, Carpenter L, Howe G, Kato I, Armstrong BK, et al. Effects of low doses and low dose rates of external ionizing radiation: cancer mortality among nuclear industry workers in three countries. Radiat Res. 1995;142:117–32.
Cited by
6 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献