A systematic approach to identify novel cancer drug targets using machine learning, inhibitor design and high-throughput screening-Reference-Cited by-同舟云学术

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A systematic approach to identify novel cancer drug targets using machine learning, inhibitor design and high-throughput screening

Published:2014-07-30 Issue:7 Volume:6 Page:
ISSN:1756-994X
Container-title:Genome Medicine
language:en
Short-container-title:Genome Med

Author:

Jeon Jouhyun,Nim Satra,Teyra Joan,Datti Alessandro,Wrana Jeffrey L,Sidhu Sachdev S,Moffat Jason,Kim Philip M

Publisher

Springer Science and Business Media LLC

Subject

Genetics (clinical),Genetics,Molecular Biology,Molecular Medicine

Link

http://link.springer.com/content/pdf/10.1186/s13073-014-0057-7.pdf

Reference93 articles.

1. Rask-Andersen M, Almen MS, Schioth HB: Trends in the exploitation of novel drug targets. Nat Rev Drug Discov. 2011, 10: 579-590. 10.1038/nrd3478.

2. Marcotte R, Brown KR, Suarez F, Sayad A, Karamboulas K, Krzyzanowski PM, Sircoulomb F, Medrano M, Fedyshyn Y, Koh JL, van Dyk D, Fedyshyn B, Luhova M, Brito GC, Vizeacoumar FJ, Vizeacoumar FS, Datti A, Kasimer D, Buzina A, Mero P, Misquitta C, Normand J, Haider M, Ketela T, Wrana JL, Rottapel R, Neel BG, Moffat J: Essential gene profiles in breast, pancreatic, and ovarian cancer cells. Cancer Discov. 2012, 2: 172-189. 10.1158/2159-8290.CD-11-0224.

3. Liotta L, Petricoin E: Molecular profiling of human cancer. Nat Rev Genet. 2000, 1: 48-56. 10.1038/35049567.

4. Beroukhim R, Mermel CH, Porter D, Wei G, Raychaudhuri S, Donovan J, Barretina J, Boehm JS, Dobson J, Urashima M, Mc Henry KT, Pinchback RM, Ligon AH, Cho YJ, Haery L, Greulich H, Reich M, Winckler W, Lawrence MS, Weir BA, Tanaka KE, Chiang DY, Bass AJ, Loo A, Hoffman C, Prensner J, Liefeld T, Gao Q, Yecies D, Signoretti S: The landscape of somatic copy-number alteration across human cancers. Nature. 2010, 463: 899-905. 10.1038/nature08822.

5. Mardis ER, Wilson RK: Cancer genome sequencing: a review. Hum Mol Genet. 2009, 18: R163-R168. 10.1093/hmg/ddp396.

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