MIR31HG polymorphisms are related to steroid-induced osteonecrosis of femoral head among Chinese Han population

Abstract

AbstractBackgroundsMIR31host gene (MIR31HG) polymorphisms play important roles in the occurrence of osteonecrosis. However, the association ofMIR31HGpolymorphisms with the risk of steroid-induced osteonecrosis of the femoral head (SONFH) remains unclear. In this study, we aimed to investigate the correlation betweenMIR31HGpolymorphisms and SONFH susceptibility in the Chinese Han population.MethodsA total of 708 volunteers were recruited to detect the effect of seven single nucleotide polymorphisms (SNPs) in the MIR31HG gene on SONFH risk in the Chinese Han population. Genotyping of MIR31HG polymorphisms was performed using the Agena MassARRAY platform. The odds ratio (OR) and 95% confidence interval (95% CI) were used to evaluate the correlation between MIR31HG polymorphisms and SONFH risk using logistic regression model.ResultsAccording to the results of genetic model, rs10965059 inMIR31HGwas significantly correlated with the susceptibility to SONFH (OR = 0.56,p = 0.002). Interestingly, the stratified analysis showed that rs10965059 was associated with the reduced risk of SONFH in subjects aged > 40 years (OR = 0.30,p < 0.001) and male populations (OR = 0.35,p < 0 .001). Moreover, rs10965059 was associated with the reduced risk of bilateral SONFH (OR = 0.50,p = 0.002). Finally, multi-factor dimension reduction (MDR) results showed that the combination of rs1332184, rs72703442, rs2025327, rs55683539, rs2181559, rs10965059 and rs10965064 was the best model for predicting SONFH occurrence (p < 0.0001).ConclusionThe study indicated that rs10965059 could be involved in SONFH occurrence in the Chinese Han population, which might provide clues for investigating the role ofMIR31HGin the pathogenesis of SONFH.