A protocol for a multicentre, randomised, double-blind, placebo-controlled trial to compare the effect of annual infusions of zoledronic acid to placebo on knee structural change and knee pain over 24 months in knee osteoarthritis patients

A protocol for a multicentre, randomised, double-blind, placebo-controlled trial to compare the effect of annual infusions of zoledronic acid to placebo on knee structural change and knee pain over 24 months in knee osteoarthritis patients – ZAP2

Published:2018-07-18 Issue:1 Volume:19 Page:
ISSN:1471-2474
Container-title:BMC Musculoskeletal Disorders
language:en
Short-container-title:BMC Musculoskelet Disord

Author:

Aitken Dawn^ORCID,Laslett Laura L.,Cai Guoqi,Hill Catherine,March Lyn,Wluka Anita E.,Wang Yuanyuan,Blizzard Leigh,Cicuttini Flavia,Jones Graeme

Funder

National Health and Medical Research Council

Publisher

Springer Science and Business Media LLC

Subject

Orthopedics and Sports Medicine,Rheumatology

Link

http://link.springer.com/content/pdf/10.1186/s12891-018-2143-2.pdf

Reference69 articles.

1. Murray CJ, Vos T, Lozano R, Naghavi M, Flaxman AD, Michaud C, et al. Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the global burden of disease study 2010. Lancet. 2012;380:2197–223.

2. Cross M, Smith E, Hoy D, Nolte S, Ackerman I, Fransen M, et al. The global burden of hip and knee osteoarthritis: estimates from the global burden of disease 2010 study. Ann Rheum Dis. 2014;73:1323–30.

3. Conaghan PG, Peloso PM, Everett SV, Rajagopalan S, Black CM, Mavros P, et al. Inadequate pain relief and large functional loss among patients with knee osteoarthritis: evidence from a prospective multinational longitudinal study of osteoarthritis real-world therapies. Rheumatology (Oxford). 2015;54:270–7.

4. Lane NE, Brandt K, Hawker G, Peeva E, Schreyer E, Tsuji W, et al. OARSI-FDA initiative: defining the disease state of osteoarthritis. Osteoarthr Cartil. 2011;19:478–82.

5. Jones G. Sources of pain in osteoarthritis: implications for therapy. Int J Clin Rheumatol. 2013;8:335–45.

Cited by 24 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Bone marrow lesions in osteoarthritis: biomarker or treatment target? A narrative review;Skeletal Radiology;2024-06-14

2. Pharmacotherapy for osteoarthritis-related pain: current and emerging therapies;Expert Opinion on Pharmacotherapy;2024-06-12

3. Effect of Intravenous Zoledronic Acid on Total Knee Replacement in Patients With Symptomatic Knee Osteoarthritis and Without Severe Joint Space Narrowing: A Prespecified Secondary Analysis of a Two‐Year, Multicenter, Double‐Blind, Placebo‐Controlled Clinical Trial;Arthritis & Rheumatology;2024-03-13

4. Bone marrow edema in osteoarthritis of the knee joint;Patient-Oriented Medicine and Pharmacy;2024-01-24

5. Indication and adverse event profiles of denosumab and zoledronic acid: based on U.S. FDA adverse event reporting system (FAERS);Frontiers in Pharmacology;2023-11-01