Abstract
AbstractSalivary gland (SG) dysfunction impairs the life quality of many patients, such as patients with radiation therapy for head and neck cancer and patients with Sjögren’s syndrome. Multiple SG engineering strategies have been considered for SG regeneration, repair, or whole organ replacement. An in-depth understanding of the development and differentiation of epithelial stem and progenitor cells niche during SG branching morphogenesis and signaling pathways involved in cell–cell communication constitute a prerequisite to the development of suitable bioengineering solutions. This review summarizes the essential bioengineering features to be considered to fabricate an engineered functional SG model using various cell types, biomaterials, active agents, and matrix fabrication methods. Furthermore, recent innovative and promising approaches to engineering SG models are described. Finally, this review discusses the different challenges and future perspectives in SG bioengineering.
Funder
Université Libre de Bruxelles
Fonds De La Recherche Scientifique - FNRS
Fonds de Recherche du Québec - Santé
Publisher
Springer Science and Business Media LLC
Subject
Pharmacology (medical),Biochemistry (medical),Cell Biology,Clinical Biochemistry,Molecular Biology,General Medicine,Endocrinology, Diabetes and Metabolism
Reference242 articles.
1. Almansoori AA, Kim B, Lee JH, Tran SD. Tissue engineering of oral mucosa and salivary gland: disease modeling and clinical applications. Micromachines. 2020;11(12):1066.
2. Tanaka J, Mishima K. In vitro three-dimensional culture systems of salivary glands. Pathol Int. 2020;70(8):493–501.
3. Edgar WM, O’Mullane DM, Dawes C. Saliva and oral health. Vol. 146. British Dental Association London; 2004.
4. von Bültzingslöwen I, Sollecito TP, Fox PC, Daniels T, Jonsson R, Lockhart PB, et al. Salivary dysfunction associated with systemic diseases: systematic review and clinical management recommendations. Oral Surg Oral Med Oral Pathol Oral Radiol Endodontology. 2007;103:S57–61.
5. Carsons SE, Patel BC. Sjogren syndrome. StatPearls Internet. 2021.
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