Abstract
AbstractBreast cancer is one of the most common malignancies that pose a serious threat to women's health. Reprogramming of energy metabolism is a major feature of the malignant transformation of breast cancer. Compared to normal cells, tumor cells reprogram metabolic processes more efficiently, converting nutrient supplies into glucose, amino acid and lipid required for malignant proliferation and progression. Non-coding RNAs(ncRNAs) are a class of functional RNA molecules that are not translated into proteins but regulate the expression of target genes. NcRNAs have been demonstrated to be involved in various aspects of energy metabolism, including glycolysis, glutaminolysis, and fatty acid synthesis. This review focuses on the metabolic regulatory mechanisms and clinical applications of metabolism-regulating ncRNAs involved in breast cancer. We summarize the vital roles played by metabolism-regulating ncRNAs for endocrine therapy, targeted therapy, chemotherapy, immunotherapy, and radiotherapy resistance in breast cancer, as well as their potential as therapeutic targets and biomarkers. Difficulties and perspectives of current targeted metabolism and non-coding RNA therapeutic strategies are discussed.
Funder
Suzhou Science, Education and Health Youth Science and Technology Project
Science and Technology Program of Suzhou
the National Natural Science Foundation of China
the Natural Science Foundation of Jiangsu Province
Gusu Talent Program; Support for the project of nuclear technology medical application supported by discipline construction
Maternal and Child Health Association Project of Jiangsu province
“National Tutor System” Training Program for Health Youth Key Talents in Suzhou
Publisher
Springer Science and Business Media LLC
Cited by
3 articles.
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