Three weekly versus weekly concurrent cisplatin: safety propensity score analysis on 166 head and neck cancer patients

Author:

Buglione Michela,Alterio Daniela,Maddalo Marta,Greco Diana,Gerardi Marianna AlessandraORCID,Tomasini Davide,Pegurri Ludovica,Augugliaro Matteo,Marvaso Giulia,Turturici Irene,Guerini Andrea,Ansarin Mohssen,Spiazzi Luigi,Costa Loredana,Cossu Rocca Maria,Magrini Stefano Maria,Jereczek-Fossa Barbara Alicja

Abstract

Abstract Background Radio-chemotherapy with CDDP is the standard for H&N squamous cell cancer. CDDP 100 mg/m2/q3 is the standard; alternative schedules are used to reduce toxicity, mostly 40 mg/m2/q1. Methods Patients were treated from 1/2010 to 1/2017 in two Radiation Oncology Centres. Propensity score analysis (PS) was retrospectively used to compare these two schedules. Results Patients analyzed were 166. Most (114/166) had 1w-CDDP while 52 had 3w-CDDP. In the 3w-CDDP group, patients were younger, with better performance status, smaller disease extent and a more common nodal involvement than in the 1w-CDDP. Acute toxicity was similar in the groups. Treatment compliance was lower in the w-CCDP. Overall survival before PS was better for female, for oropharyngeal disease and for 3w-CDDP group. After PS, survival was not related to the CDDP schedule. Conclusions 3w-CDDP remains the standard for fit patients, weekly schedule could be safely used in selected patients.

Publisher

Springer Science and Business Media LLC

Subject

Radiology, Nuclear Medicine and imaging,Oncology

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