Abstract
Abstract
Background
In this study, the potential anticancer activity and mechanism of action of SBD-2, a chalcone isolated from Shuteria involucrata, was investigated in colorectal cancer (CRC) cells.
Results
SBD-2 inhibited the proliferation of Caco-2 cells in a dose-dependent manner. It elicited the cells arrested in the G2/M phase and induced apoptosis. Mechanistically, SBD-2 inhibited Akt phosphorylation, which suppressed the ani-apoptotic protein Bcl-2 and cell cycle regulator Cyclin B1, leading to apoptosis ad cycle arrest, respectively.
Conclusions
The presented chalcone compound SBD-2 from Shuteria involucrata induced apoptosis and cell cycle arrest through inhibiting Akt pathway, highlighting the possibility to develop as a new agent for CRC treatment.
Funder
the Science and Technology Development Fund of the Macau Special Administrative Region
the National Natural Science Foundation of China
the Reserve Talents Project for Young and Middle-Aged Academic and Technical Leaders of Yunnan Province
Applied Basic Research Key Project of Yunnan
the Key Laboratory of Yunnan Provincial Department of Education on Substance Benchmark Research of Ethnic Medicines
Publisher
Springer Science and Business Media LLC