Author:
Abebe Atakilt,Bayeh Yosef,Belay Minale,Gebretsadik Tesfay,Thomas Madhu,Linert Wolfgang
Abstract
Abstract
Background
Coordination compounds, in particular cobalt(II) mixed ligand complexes containing 1,10-phenantroline, have drawn the attention of many investigators as some of them are showing antimicrobial activities.
Result
Herein, we report three novel mixed ligand complexes of cobalt(II) having the formulae [Co(L1)2(H2O)2]Cl2, [Co(L1)2(L2)(H2O)]Cl2 and [Co2(L1)4(L2)2(L3)]Cl4 (L1 = 1,10-phenanthroline, L2 = adenine, L3 = 1,3-diaminepropane) were synthesized and characterized by elemental analysis, conductivity measurement, infrared, and UV-Vis spectroscopic techniques. Octahedral geometries are proposed to all the complexes. In vitro antibacterial activities of the ligands, salt, and metal complexes were tested on four pathogenic bacteria (Staphylococcus aureus, Salmonella typhus, Escherichia coli, and Staphylococcus epidermis) using disc diffusion method.
Conclusions
It is interesting to note that the newly synthesized cobalt(II) complexes are active against gram negative bacteria (Escherichia coli and Klebsiella pneumoniae) even though cobalt(II) complexes are well known for their activity against gram positive bacteria.
Publisher
Springer Science and Business Media LLC
Reference49 articles.
1. Boyer JL, Rochfor J, Tsai M-K, Muckerman JT, Fujita E (2010) Ruthenium complexes with non-innocent ligands: electron distribution and implications for catalysis. Coord Chem Rev 254:309–330
2. Goo YR, Maity AC, Cho KB, Lee YM, Seo MS, Park YJ, Cho J, Wonwoo NW (2015) Tuning the reactivity of chromium(III)-superoxo species by coordinating axial ligands. Inorg Chem 54:10513–10520
3. Tolman CA (1977) Steric effects of phosphorus ligands in organometallic chemistry and homogeneous catalysis. Chem Rev 77:313–348
4. Abebe A, Tamiru G (2018) Hexacationic coordination compound from Co(II) and a cationic ligand derived from 4,4′-bipyridine: synthesis, characterization and investigation for biological application. Cogent Chemistry 4:156–162
5. Mohapatra B, Verma S (2013) Crystal engineering with modified 2-aminopurine and Group 12 metal ions. Cryst Growth Des 13:2716–2721
Cited by
15 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Synthesis, characterization and comprehensive study of a 3D Co(II) coordination polymer antibacterial activity;Journal of Molecular Structure;2023-07
2. Organic–inorganic hybrid salt and mixed ligand Cr(III) complexes containing the natural flavonoid chrysin: Synthesis, characterization, computational, and biological studies;Frontiers in Chemistry;2023-04-12
3. Cytotoxicity and Antibacterial Potentials of Mixed Ligand Cu(II) and Zn(II) Complexes: A Combined Experimental and Computational Study;ACS Omega;2023-03-29
4. Molecular Docking, DFT, and Antibacterial Activity Study of a Newly Synthesized Mixed Ligand Complex of Co(II), 1,10-Phenanthroline, Adenine and Acetamide;Chemistry Africa;2023-03-22
5. Synthesis, physicochemical, quantitative analysis and crystal structures of two mononuclear diperchlorate cobalt(II) complexes of 1,10-phenanthroline: antimicrobial, cytotoxicity and DNA/BSA interaction studies;Structural Chemistry;2022-12-17