Antidiabetic and antihyperlipidemic activities of Cucumis melo var. momordica fruit extract on experimental animals

Abstract

AbstractBackgroundDiabetes mellitus is a major public health issue related to the irregular metabolism of carbohydrates, protein, and fat. It occurs due to insufficient insulin production and insulin action.Cucumis melopossesses several biological properties including antioxidant, anti-inflammatory, antibacterial, antihypothyroidism, and antiangiogenic activities. The objective of the present study was to determine the antidiabetic and antihyperlipidemic activities ofCucumis melovar.momordicafruit extract on experimental animals.ResultResults show that treatment withC. melofruit extract and fraction caused a reduction in blood glucose levels.Cucumis melotoluene fraction (CMTF) exhibited a significant (*P< 0.05) reduction of blood glucose level on the 28th day, i.e., 122 mg/dL, in comparison with the positive control group (streptozotocin (STZ)). However, the extract ofC. meloshowed less significant results in comparison with CMTF. Triglyceride, LDL, and VLDL levels were increased chronically due to STZ and were significantly (*P< 0.05) restored to 84.16, 86.97, and 19.73, respectively, by CMTF in comparison with the positive control group (STZ in the dose of 55 mg/kg). The extract-treated groups also showed similar results as CMTF, but their efficacy was lesser than CMTF.ConclusionIt is can be concluded thatC. melofruits can be used as an effective antidiabetic and antihyperlipidemic drug.Graphical abstract