EGFR T790M relative mutation purity predicts osimertinib treatment efficacy in non‐small cell lung cancer patients

Author:

Zheng Qiufan1,Hong Shaodong1,Huang Yan1,Zhao Hongyun2,Yang Yunpeng1,Hou Xue1,Zhao Yuanyuan1,Ma Yuxiang2,Zhou Ting1,Zhang Yaxiong1,Fang Wenfeng1,Zhang Li1

Affiliation:

1. Department of Medical OncologyState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineSun Yat‐Sen University Cancer Center510060GuangzhouGuangdongChina

2. Department of Clinical ResearchState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineSun Yat‐Sen University Cancer Center510060GuangzhouGuangdongChina

Funder

National Key R&D Program of China

Science and Technology Planning Project of Guangdong Province

Guangzhou Science and Technology Program key projects

Young Scientists Fund

National Natural Science Foundation of China

Pearl River S and T Nova Program of Guangzhou

Young Teacher Foundation of Sun Yat-sen University

Publisher

Wiley

Subject

Molecular Medicine,Medicine (miscellaneous)

Reference35 articles.

1. Pan‐Asian adapted clinical practice guidelines for the management of patients with metastatic non‐small‐cell lung cancer: a CSCO‐ESMO initiative endorsed by JSMO, KSMO, MOS, SSO and TOS;Wu YL;Ann Oncol,2019

2. Osimertinib or platinum‐pemetrexed in EGFR T790M‐positive lung cancer;Mok TS;N Engl J Med,2017

3. AZD9291 in EGFR inhibitor‐resistant non‐small‐cell lung cancer;Janne PA;N Engl J Med,2015

4. Osimertinib for pretreated EGFR Thr790Met‐positive advanced non‐small‐cell lung cancer (AURA2): a multicentre, open‐label, single‐arm, phase 2 study;Goss G;Lancet Oncol,2016

5. Heterogeneity underlies the emergence of EGFRT790 wild‐type clones following treatment of T790M‐positive cancers with a third‐generation EGFR inhibitor;Piotrowska Z;Cancer Discov,2015

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