Author:
Sheng Dong,Zhang Yan,Xue Tian,Zhou Xiao-Yan,Li Xiao-Qiu
Abstract
Abstract
Background
The distinction between acinic cell carcinoma (ACC) and secretory carcinoma (SC) of the salivary gland is hampered by the lack of specific diagnostic markers. It is known the cytoplasm of glandular cells in the salivary gland immunohistochemically expresses LIM Domain Only 2 (LMO2). Herein, we aim to evaluate the expression status of LMO2 in a large cohort of tumors of the salivary gland, with an emphasis on its significance in the distinction of ACC and SC.
Methods
Immunohistochemical stains were performed to evaluate the expression of LMO2 in normal tissues and tumors of salivary gland.
Results
LMO2 was expressed in normal serous acinar cells of the salivary gland. We also found the cytoplasmic immunostaining of LMO2 was specific and sensitive for the recognition of ACCs including those with morphological overlaps with SCs, whereas the cytoplasmic expression of LMO2 was not detected in SCs.
Conclusions
LMO2 is useful for the recognition of ACC and is of potential value in distinguishing ACC from SC.
Funder
science and technology commission of shanghai municipality
natural science foundation of shanghai
Publisher
Springer Science and Business Media LLC
Subject
General Medicine,Histology,Pathology and Forensic Medicine