Squamous cell carcinoma with sarcomatoid differentiation or carcinosarcoma of the uterine cervix associated with HPV33 infection: report of a rare case

Author:

Hrudka JanORCID,Rosová Blanka,Halaška Michael J.

Abstract

Abstract Background Squamous cell carcinoma is the most common malignant tumor of the uterine cervix with a well-documented link to infection with human papillomaviruses (HPV). According to a recent classification, there are several morphological variants of cervical squamous carcinoma, without reference to sarcomatoid squamous cell carcinoma, which is well described in other organs. Case presentation In this paper, we describe an extremely rare case of a 77-year-old woman with primary malignant cervical tumor displaying biphasic histomorphology with an epithelioid and sarcomatoid part; the latter was immunohistochemistry positive for cytokeratin and vimentin. The association with a high-grade squamous intraepithelial lesion and molecular proof of HPV33 infection in the tumor tissue supported our diagnosis of carcinoma with partial sarcomatoid differentiation. Conclusion We report a rare case of a primary cervical epithelial tumor with a partial sarcomatoid phenotype, an unequivocal HPV infection, and an associated precancerous lesion in the cervical mucosa. This is the first description of an HPV33 infection underlying a biphasic epithelioid-sarcomatous tumor of the uterine cervix. The terminology overlap between sarcomatoid carcinoma and carcinosarcoma is also discussed.

Funder

Univerzita Karlova v Praze

Publisher

Springer Science and Business Media LLC

Subject

General Medicine,Histology,Pathology and Forensic Medicine

Reference19 articles.

1. Stoler M, Bergeron C, Colgan TJ, Ferenczy AS, Herrington CS, Kim KR, et al. Squamous cell tumours and precursors. In: Kurman RJ, Carcangiu ML, Herrington CS, Young RH, editors. WHO Classification of Tumours of Female Reproductive Organs. Lyon: IARC; 2014. p. 176–81.

2. Pirog EC, Wright TC, Ronnett BM, Kurman RJ. Carcinoma and other tumors of the cervix. In: Kurman RJ, Ellenson LH, Ronnett BM, editors. Blaustein’s Pathology of the Female Genital Tract, 7th Edition. Springer Nature Switzerland AG; 2019. p. 316–38.

3. Terada T. Sarcomatoid squamous cell carcinoma of the uterine cervix. Arch Gynecol Obstet. 2010;282:231–2.

4. Rodrigues L, Santana I, Cunha T, Félix A, Freire J, Cabral I. Sarcomatoid squamous cell carcinoma of the uterine cervix: case report. Eur J Gynaecol Oncol. 2000;21:287–9.

5. Kumar M, Bahl A, Sharma DN, Agarwal S, Halanaik D, Kumar R, Rath GK. Sarcomatoid squamous cell carcinoma of the uterine cervix: pathology, imaging, and treatment. J Cancer Res Ther. 2008;4:39–41.

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