Author:
Tang Hao,He Yutao,Chen Ying,Xu Wenfeng,Xu Yujuan,Li Xianyun,Guo Deyu
Abstract
Abstract
Background
Sinonasal mucosal melanoma (SNMM) is a rare malignant melanoma originating from melanocytes derived from multipotent neural crest cells. Its incidence accounts for less than 1 % of all malignant melanomas, with five-year survival rate about 25 %. Occasionally, it is incredibly formidable to make a compelling diagnosis when malignant melanoma with other diverse differentiation.
Case presentation
Herein, we presented a 54-year-old male case of SNMM with smooth muscle differentiation, defined by histopathology and positive immunostaining for the smooth muscle specific markers of a-SMA, H-caldesmon, calponin and Desmin, as well as specific melanocyte markers of HMB-45, Melan-A, SOX10, and PNL2.
Conclusions
Mucosal melanoma with smooth muscle differentiation is remarkably infrequent, and reported only 4 cases to date. It would be a potential pathological diagnostic pitfall. It is important to understand this variation of malignant melanoma for avoiding misdiagnosis.
Publisher
Springer Science and Business Media LLC
Subject
General Medicine,Histology,Pathology and Forensic Medicine
Reference24 articles.
1. Kaur K, Kakkar A, Rastogi S, et al. Sinonasal amelanotic melanoma with neuroendocrine differentiation: a diagnostic conundrum. Ultrastruct Pathol. 2020;44(2):249–54.
2. Lerner BA, Stewart LA, Horowitz DP, et al. Mucosal melanoma: new insights and therapeutic options for a unique and aggressive disease. Oncology (Williston Park). 2017;31(11):e23–32.
3. Mikkelsen LH, Larsen AC, von Buchwald C, et al. Mucosal malignant melanoma - a clinical, oncological, pathological and genetic survey. APMIS. 2016;124(6):475–86.
4. Mihajlovic M, Vlajkovic S, Jovanovic P, et al. Primary mucosal melanomas: a comprehensive review. Int J Clin Exp Pathol. 2012;5(8):739–53.
5. Mochel MC, Duncan LM, Piris A, et al. Primary mucosal melanoma of the sinonasal tract: a clinicopathologic and immunohistochemical study of thirty-two cases. Head Neck Pathol. 2015 Jun;9(2):236–43.