Author:
Harrison Mary K,Adon Arsene M,Saavedra Harold I
Abstract
Abstract
Because centrosome amplification generates aneuploidy and since centrosome amplification is ubiquitous in human tumors, a strong case is made for centrosome amplification being a major force in tumor biogenesis. Various evidence showing that oncogenes and altered tumor suppressors lead to centrosome amplification and aneuploidy suggests that oncogenes and altered tumor suppressors are a major source of genomic instability in tumors, and that they generate those abnormal processes to initiate and sustain tumorigenesis. We discuss how altered tumor suppressors and oncogenes utilize the cell cycle regulatory machinery to signal centrosome amplification and aneuploidy.
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology,Molecular Biology,Biochemistry
Reference168 articles.
1. Lothschutz D, et al.: Polyploidization and centrosome hyperamplification in inflammatory bronchi. Inflamm Res 2002,51(8):416–22. 10.1007/PL00000323
2. Zyss D, Gergely F: Centrosome function in cancer: guilty or innocent? Trends Cell Biol. 2009,19(7):334–46.
3. Pihan GA, et al.: Centrosome defects and genetic instability in malignant tumors. Cancer Research 1998,58(17):3974–85.
4. Pihan GA, et al.: Centrosome abnormalities and chromosome instability occur together in pre-invasive carcinomas. Cancer Res 2003,63(6):1398–404.
5. Carroll PE, et al.: Centrosome hyperamplification in human cancer: chromosome instability induced by p53 mutation and/or Mdm2 overexpression. Oncogene 1999,18(11):1935–44. 10.1038/sj.onc.1202515
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