Abstract
AbstractCancer stem cells (CSCs) are a subpopulation of cancer cells with stem cell properties that sustain cancers, which may be responsible for cancer metastasis or recurrence. Lipid rafts are cholesterol- and sphingolipid-enriched microdomains in the plasma membrane that mediate various intracellular signaling. The occurrence and progression of cancer are closely related to lipid rafts. Emerging evidence indicates that lipid raft levels are significantly enriched in CSCs compared to cancer cells and that most CSC markers such as CD24, CD44, and CD133 are located in lipid rafts. Furthermore, lipid rafts play an essential role in CSCs, specifically in CSC self-renewal, epithelial-mesenchymal transition, drug resistance, and CSC niche. Therefore, lipid rafts are critical regulatory platforms for CSCs and promising therapeutic targets for cancer therapy.
Funder
the National Natural Sciences Foundation of China
the Key Project of the Educational Department of Hunan Province
Pharmaceutical Open Fund of Domestic First-class Disciplines (cultivation) of Hunan Province
the Scientific Research Project of Changsha Science and Technology Bureau
Key Project of Hunan Provincial Health Commission
the Graduate Research innovation project of Hunan University of Chinese Medicine
the First-Class Discipline of Pharmaceutical Science of Hunan
Natural Science Foundation of Hunan Province
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology,Biochemistry, Genetics and Molecular Biology (miscellaneous),Molecular Medicine,Medicine (miscellaneous)
Cited by
19 articles.
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