Author:
Fu Yun-Xing,Ji Jing,Shan Fang,Li Jialing,Hu Rong
Abstract
AbstractPremature ovarian failure (POF) is one of the common disorders found in women leading to 1% female infertility. Clinical features of POF are hypoestrogenism or estrogen deficiency, increased gonadotropin level, and, most importantly, amenorrhea. With the development of regenerative medicine, human mesenchymal stem cell (hMSC) therapy brings new prospects for POF. This study aimed to describe the types of MSCs currently available for POF therapy, their biological characteristics, and their mechanism of action. It reviewed the latest findings on POF to provide the theoretical basis for further investigation and clinical therapy.
Funder
National Natural Science Foundation of China
First-Class Discipline Construction Founded Project of Ning Xia Medical University
2018 Advantageous Subjects Project of NingXia Medical University
Key Research and Development program of Ningxia Hui Autonomous Region
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology,Biochemistry, Genetics and Molecular Biology (miscellaneous),Molecular Medicine,Medicine (miscellaneous)
Reference147 articles.
1. Coulam CB. Premature gonadal failure. Fertil Steril. 1982;38(6):645–55.
2. Pastore LM, Christianson MS, Stelling J, et al. Reproductive ovarian testing and the alphabet soup of diagnoses: DOR, POI, POF, POR, and FOR. J Assist Reprod Genet. 2018;35(1):17–23.
3. Orlandini C, Regini C, Vellucci FL, Petraglia F, Luisi S. Genes involved in the pathogenesis of premature ovarian insufficiency. Minerva Ginecol. 2015;67(5):421–30.
4. Ebrahimi M, Asbagh FA. The role of autoimmunity in premature ovarian failure. Iran J Reprod Med. 2015;13(8):461.
5. Yan G, Schoenfeld D, Penney C, Hurxthal K, Taylor AE, Faustman D. Identification of premature ovarian failure patients with underlying autoimmunity. J Womens Health Gend Based Med. 2000;9(3):275–87.
Cited by
54 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献