Ex vivo cultivated oral mucosal epithelial cell transplantation for limbal stem cell deficiency: a review-Reference-Cited by-同舟云学术

Ex vivo cultivated oral mucosal epithelial cell transplantation for limbal stem cell deficiency: a review

Published:2020-07-21 Issue:1 Volume:11 Page:
ISSN:1757-6512
Container-title:Stem Cell Research & Therapy
language:en
Short-container-title:Stem Cell Res Ther

Author:

Cabral Joao Victor,Jackson Catherine Joan,Utheim Tor Paaske,Jirsova Katerina^ORCID

Abstract

AbstractDestruction or dysfunction of limbal epithelial stem cells (LESCs) leads to unilateral or bilateral limbal stem cell deficiency (LSCD). Fifteen years have passed since the first transplantation of ex vivo cultivated oral mucosal epithelial cells (COMET) in humans in 2004, which represents the first use of a cultured non-limbal autologous cell type to treat bilateral LSCD. This review summarizes clinical outcomes from COMET studies published from 2004 to 2019 and reviews results with emphasis on the culture methods by which grafted cell sheets were prepared.

Funder

Univerzita Karlova v Praze

Ministerstvo Školství, Mládeže a Tělovýchovy

Publisher

Springer Science and Business Media LLC

Subject

Cell Biology,Biochemistry, Genetics and Molecular Biology (miscellaneous),Molecular Medicine,Medicine (miscellaneous)

Link

https://link.springer.com/content/pdf/10.1186/s13287-020-01783-8.pdf

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