Author:
Blankson Samuel Odarkwei,Dadjé Danielle Seri,Traikia Nadjla,Alao Maroufou J.,Ayivi Serge,Amoussou Annick,Deloron Philippe,Ndam Nicaise Tuikue,Milet Jacqueline,Basco Leonardo K.,Aniweh Yaw,Tahar Rachida
Abstract
Abstract
Background
Cytoadhesion and sequestration of Plasmodium falciparum infected red blood cells (iRBC) in the microvasculature of vital organs are a major cause of malaria pathology. Several studies have provided evidence on the implication of the human host intercellular adhesion molecule-1 (ICAM-1) as a major receptor for iRBCs binding to P. falciparum erythrocyte membrane protein 1 (PfEMP1) in the development of severe and cerebral malaria. The genetic polymorphism K29M in the immunoglobulin-like domain of ICAM-1, known as ICAM-1Kilifi, has been associated with either increased or decreased risk of developing cerebral malaria.
Methods
To provide more conclusive results, the genetic polymorphism of ICAM-1Kilifi was assessed by PCR and sequencing in blood samples from 215 Beninese children who presented with either mild or severe malaria including cerebral malaria.
Results and conclusions
The results showed that in this cohort of Beninese children, the ICAM-1kilifi variant is present at the frequencies of 0.27, similar to the frequency observed in other African countries. This ICAM-1kilifi variant was not associated with disease severity in agreement with other findings from the Gambia, Tanzania, Malawi, Gabon, and Thailand, suggesting no evidence of a direct link between this polymorphism and the pathogenesis of severe and cerebral malaria.
Funder
the SCAC – Cultural and Cooperation Department - French Embassy in Ghana
Ghana Scholarships Secretariat.
Institut de Recherche pour le Développement
Publisher
Springer Science and Business Media LLC
Subject
Infectious Diseases,Parasitology
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